Simulating clinical trials
Simulating clinical trials for model-informed precision dosing: Using warfarin treatment as a use case.
tbdDoctoral Candidate in Computer Science
Hi, I'm David! I'm a doctoral candidate in Computer Science at the University of Oxford. I'm interested in pharmacological modelling approaches which speed up the drug development process, and improve the treatment of patients in clinical practice. An example of such a modelling approach is pharmacokinetic and pharmacodynamic (PKPD) modelling. PKPD modelling can be used in an academic setting to understand drugs and their interaction with the human body. In clinical practice, PKPD models also have the potential to personalise dosing strategies such that unintended adverse effects of drugs are avoided, and the treatment outcome for each patient is optimised.
My research evolves around improving the PKPD modelling approach itself, but also involves modelling the PKPD properties of individual drugs, such as the anti-cancer drugs erlotinib and gefitinib.
This fundamentally interdisciplinary research would not be possible without the immensely helpful supervision of Dave Gavaghan, Antje-Christine Walz, Ken Wang, Ben Lambert and Martin Robinson, whose expertise in
is elementary to the success of my research. In an attempt to make PKPD modelling accessible to the wider community (including pharmacologists and physicians with potentially little programming experience), me and a team of other software engineers are developing the PKPDApp - an open-source web application which allows users to model the PKPD of drugs and predict optimal treatment strategies.
My formal education is in Mathematics and Physics, or more broadly speaking - how mathematical concepts can be used to quantify and understand what is happening around us. With the addition of computational skills and software engineering in the more recent years, I am now trying to make some of these concepts applicable to every day problems, such as personalised medication and treatment of diseases.
University of Oxford, Oxford, UK
I am researching the potential of PKPD modelling to inform personalised treatment strategies for patients in clinical practice.
University of Cologne, Cologne, Germany
Specialising in Statistical Physics and Biophysics, I investigated the predictability of evolution in haploids in a dynamic regime where selection is strong and mutations are too rare for mutational interference to occur.
University of Cambridge, Cambridge, UK
Part III of the Mathematical Tripos in Cambridge is a purely taught course, in which I specialised in High Energy Physics, and learned about Quantum Field Theories, String Theory and General Relativity.
Humboldt University, Berlin, Germany
With a minor in mathematics, I studied the postulated duality between a special class of Quantum Field Theories in Minkowski space time and String Theory in curved Anti-de Sitter space time.
Department of Computer Science, University of Oxford, UK
Department of Computer Science, University of Oxford, UK
Doctoral Training Centre, University of Oxford, UK
Institute for Theoretical Physics, University of Cologne, Germany
Institute for Theoretical Physics, University of Cologne, Germany
Institute for Theoretical Physics, University of Cologne, Germany
Institute for Theoretical Physics, University of Cologne, Germany
I am currently based in Oxford, UK. If you are interested in my research or would like to initiate a collaboration, please feel welcome to get in touch.
15 Parks Rd, Oxford OX1 3QD
david.augustin@cs.ox.ac.uk
https://github.com/DavAug